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Pharmacokinetics of CS-023 (RO4908463), a Novel Parenteral Carbapenem, in Healthy Male Caucasian Volunteers

2006; American Society for Microbiology; Volume: 50; Issue: 12 Linguagem: Inglês

10.1128/aac.00494-06

1098-6596

Takahiro Shibayama, Yoko Matsushita, Takashi Hirota, Toshihiko Ikeda, Shōgo Kuwahara,

Pneumonia and Respiratory Infections

The CS-023 concentration in plasma after administration by infusion to healthy volunteers at a dose of 700 mg was decreased, with a half-life of 1.7 h, and the cumulative urinary excretion was 59.4% of the dose. The total clearance, renal clearance, and volume of distribution were 8.12 liters/h, 4.14 liters/h, and 17.2 liters, respectively.