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Artigo Acesso aberto Produção Nacional
BIBTEX RIS

Molecular epidemiology of dengue virus serotypes 2 and 3 isolated in Brazil from 1991 to 2008

2010; Volume: 1; Issue: 3 Linguagem: Inglês

10.5123/s2176-62232010000300004

ISSN

2176-6223

Autores

Ana Cecília Ribeiro Cruz, Ricardo Galler, Eliana Vieira Pinto da Silva, Mayra de Oliveira e Silva, Adriana Ribeiro Carneiro, Elizabeth Salbé Travassos da Rosa, Helena Baldez Vasconcelos, Eric Luiz Rodrigues de Sá, Pedro Fernando da Costa Vasconcelos,

Tópico(s)

Vector-borne infectious diseases

Resumo

The dengue virus (DENV1-4) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) in tropical and subtropical areas. The aim of this study was to evaluate the circulating genotypes of DENV. This was accomplished by sequencing the PrM and E genes of Brazilian isolates of DENV2 and DENV3 that were obtained between 1991 and 2008 from various geographic regions. Phylogenetic analyses of DENV2 demonstrated that the genotype III (Southeast Asian/American), in spite of several nucleotide and amino acid changes, was the only one that circulated over the past 19 years. Since its introduction in 2000, the DENV3 isolates that have been analyzed have all grouped into genotype III (Indian subcontinent) and there has been no evidence of DENV3 belonging to other genotypes in this study.

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