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AT1 and AT2 receptor in the kidney: role in health and disease

2004; Elsevier BV; Volume: 24; Issue: 2 Linguagem: Inglês

10.1016/j.semnephrol.2003.11.009

1558-4488

Helmy M. Siragy,

Apelin-related biomedical research

The renin angiotensin system plays an important role in the control of body fluid and electrolyte homeostasis and blood pressure regulation. Angiotensin II is the most effector hormone of this system and functions mainly through stimulation of its subtype receptors, namely, the AT1 and AT2 receptors. Most of the known physiological and pathologic effects of angiotensin II are mediated through stimulation of the AT1 receptor. The knowledge about the involvement of the AT2 receptor in physiological and pathologic processes is still evolving. In the kidney, both the AT1 and AT2 receptors contribute to the regulation of renal hemodynamic and tubular functions. Also, these receptors regulate renal cellular growth and matrix formation. However, AT2 receptor possesses functions that counteract the effects of the AT1 receptor. The balance between the AT1 and AT2 receptors can determine the renal status in health and disease.