Genotoxic activity of halogenated phenylglycine derivatives
2006; Elsevier BV; Volume: 16; Issue: 23 Linguagem: Inglês
10.1016/j.bmcl.2006.08.111
ISSN1464-3405
AutoresAlicia Boto, Juan Antonio Gallardo, Rosendo Hernández, Francisco José da Silva Lédo, Ana M Muñoz‐Mármol, José Ramón Murguía, Mauricio Menacho-Márquez, Aurelio Orjales, Carlos J. Saavedra,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoThe discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.
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