Portal de Periódicos da CAPES

Novel Chemical Mediators in the Resolution of Inflammation: Resolvins and Protectins

2006; Elsevier BV; Volume: 24; Issue: 2 Linguagem: Inglês

10.1016/j.atc.2006.01.003

1558-4259

Charles N. Serhan,

Cholesterol and Lipid Metabolism

This article describes two novel families of compounds, resolvins and protectins, that carry potent biological actions and biosynthetic pathways from eicosapentaenoic acid and docosahexaenoic acid, the major omega-3 polyunsaturated fatty acids (PUFA) present in fish oils. The biosynthesis of resolvins and protectins and their roles in inflammatory exudates uncovered to date indicate that the resolution of acute inflammation is, in fact, an active process governed by biochemical pathways under genetic and nutritional control because omega-3 PUFA are widely appreciated as essential fatty acids. These new results link them to previously uncharted pathways and roles as precursors in the resolution of acute inflammation and tissue injury. Moreover, the resolvins and protectins are potent agonists of endogenous anti-inflammation and are pro-resolving chemical mediators.