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Sensory Adaptation in Naive Peripheral CD4 T Cells

2001; Rockefeller University Press; Volume: 194; Issue: 9 Linguagem: Inglês

10.1084/jem.194.9.1253

1540-9538

Katy Smith, Benedict Seddon, Marco A. Purbhoo, Rose Zamoyska, Amanda G. Fisher, Matthias Merkenschlager,

Immunotherapy and Immune Responses

T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca2+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.