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Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis

1997; Oxford University Press; Volume: 39; Issue: 5 Linguagem: Inglês

10.1093/jac/39.5.643

1460-2091

C. Pérez‐Giraldo,

Polymer Surface Interaction Studies

The influence of various concentrations (0.003-8 mg/mL) of N-acetylcysteine on the formation of biofilms by 15 strains of Staphylococcus epidermidis has been studied. A dose-related decrease in biofilm formation was observed, except with the lowest concentrations. The 'slime' index relative to the control was 63%, 55%, 46%, 34%, 26% and 26% in the presence of 0.25, 0.5, 1, 2, 4, and 8 mg/mL of N-acetylcysteine, respectively. These data are statistically significant. The inhibitory effect of 2 mg/mL of N-acetylcysteine on slime formation was also verified by electron microscopy.