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BIBTEX RIS

Reactive and Bioactive Cationic α‐Helical Polypeptide Template for Nonviral Gene Delivery

2011; Wiley; Volume: 51; Issue: 5 Linguagem: Inglês

10.1002/anie.201104262

ISSN

1521-3773

Autores

Nathan P. Gabrielson, Hua Lu, Lichen Yin, Dong Li, Fei Wang, Jianjun Cheng,

Tópico(s)

Virus-based gene therapy research

Resumo

At every turn: Poly(γ-(4-vinylbenzyl)-L-glutamate) (PVBLG) is a bioactive and reactive template for a library of cationic α-helical polypeptides (PVBLGn-X) for gene delivery. The top-performing PVBLGn-X outperformed polyethyleneimine (PEI) by 12-fold. Preliminary data indicate that the helicity of the polypeptides is essential for their performance, and enhanced membrane disruption is a likely source of their transfection efficiency. RLU=relative light unit.

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