Portal de Periódicos da CAPES

Peptide and protein thioester synthesis via N→S acyl transfer

2010; Royal Society of Chemistry; Volume: 8; Issue: 9 Linguagem: Inglês

10.1039/b925075a

1477-0539

Jaskiranjit Kang, Derek Macmillan,

Peptidase Inhibition and Analysis

Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In this Emerging Area we highlight recent developments in a somewhat surprising route to thioesters: selective disruption of amides, the more stable carboxylic acid derivatives.