Subjective visual halos after sildenafil (Viagra) administration
2001; Elsevier BV; Volume: 108; Issue: 5 Linguagem: Inglês
10.1016/s0161-6420(00)00648-5
ISSN1549-4713
AutoresC. Balacco Gabrieli, Federico Regine, Enzo Maria Vingolo, Eduardo Rispoli, Andrea Fabbri, Andrea M. Isidori,
Tópico(s)Hormonal and reproductive studies
ResumoThe ophthalmologic and electroretinographic (ERG) findings in one subject with subjective visual disturbances after sildenafil administration are described.Interventional case report.A complete ophthalmologic examination was performed, including best-corrected visual acuity and ERG, repeated 1 and 2 hours after administration of 100 mg of sildenafil.Rod responses were obtained over a range of retinal illuminances from those producing a minimum detectable response to those producing rod saturation. Intensity amplitude function was determined.At 2 hours after 100 mg of oral sildenafil, we observed significant variations from baseline in parameters of best-fit Naka-Rushton function; V(max) was notably higher, and K was 0.14 log units lower than baseline.Sildenafil administration resulted in a higher rod response to light stimuli and in a higher rod sensitivity. These findings are consistent with the weak PDE-6 inhibition induced by sildenafil.
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