Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone

2014; Oxford University Press; Volume: 16; Issue: 9 Linguagem: Inglês

10.1093/neuonc/nou005

ISSN

1523-5866

Autores

Remco J. Molenaar, Dagmar Verbaan, Simona Lamba, Carlo Zanon, Judith W. M. Jeuken, Sandra Boots‐Sprenger, Pieter Wesseling, Theo J.M. Hulsebos, Dirk Troost, Angela A. van Tilborg, Sieger Leenstra, W. Peter Vandertop, Alberto Bardelli, Cornelis J.F. Van Noorden, Fonnet E. Bleeker,

Tópico(s)

Epigenetics and DNA Methylation

Resumo

BackgroundGenetic and epigenetic profiling of glioblastomas has provided a comprehensive list of altered cancer genes of which only O6-methylguanine-methyltransferase (MGMT) methylation is used thus far as a predictive marker in a clinical setting. We investigated the prognostic significance of genetic and epigenetic alterations in glioblastoma patients.

Referência(s)