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5-Flourouracil–Induced Encephalopathy in Parkinson’s disease

2011; Volume: 22; Issue: 1 Linguagem: Inglês

10.4999/uhod.10041

1306-133X

Taner Korkmaz,

Electrolyte and hormonal disorders

A 59 year-old male with Parkinson's disease developed encephalopathy during adjuvant treatment of rectal cancer.Acute neurotoxicity related to high dose 5-Flourouracil infusion is well described, but encephalopathy with low dose bolus 5-Flourouracil is rare.The advanced Parkinson's disease patients may be more prone to hyperammonemia associated encephalopathy caused by 5-Flourouracil .The prompt recognition of the symptoms is key to diagnosis and treatment.