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Structure–activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

2006; Elsevier BV; Volume: 17; Issue: 5 Linguagem: Inglês

10.1016/j.bmcl.2006.11.056

1464-3405

Ke Wang, Jinfeng Li, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan,

RNA Interference and Gene Delivery

Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure–activity relationship (SAR) of Nec-5 series in inhibiting necroptosis.