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Olfactory identification and discrimination in obsessive-compulsive disorder

2011; Wiley; Volume: 28; Issue: 10 Linguagem: Inglês

10.1002/da.20836

1520-6394

Cinto Segalàs, Javier Labad, Pino Alonso, Eva Real, Marta Subirà, Blanca Bueno, Susana Jiménez‐Múrcia, José M. Menchón,

Biochemical Analysis and Sensing Techniques

Depression and AnxietyVolume 28, Issue 10 p. 932-940 Research Article Olfactory identification and discrimination in obsessive-compulsive disorder† Cinto Segalàs M.D., Corresponding Author Cinto Segalàs M.D. [email protected] OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainDeparment of Psychiatry, Hospital Universitario de Bellvitge, c/Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Barcelona, SpainSearch for more papers by this authorJavier Labad M.D., Javier Labad M.D. Hospital Psiquiatric Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Reus, SpainSearch for more papers by this authorPino Alonso M.D. Ph.D., Pino Alonso M.D. Ph.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, SpainSearch for more papers by this authorEva Real M.D., Eva Real M.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainSearch for more papers by this authorMarta Subirà M.D., Marta Subirà M.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, SpainSearch for more papers by this authorBlanca Bueno Psych., Blanca Bueno Psych. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainSearch for more papers by this authorSusana Jiménez-Murcia Psych. Ph.D., Susana Jiménez-Murcia Psych. Ph.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain CIBEROBN (Ciber Fisiopatologia Obesidad y Nutrición), Instituto Salud Carlos III, SpainSearch for more papers by this authorJosé M. Menchón M.D. Ph.D., José M. Menchón M.D. Ph.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, SpainSearch for more papers by this author Cinto Segalàs M.D., Corresponding Author Cinto Segalàs M.D. [email protected] OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainDeparment of Psychiatry, Hospital Universitario de Bellvitge, c/Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Barcelona, SpainSearch for more papers by this authorJavier Labad M.D., Javier Labad M.D. Hospital Psiquiatric Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Reus, SpainSearch for more papers by this authorPino Alonso M.D. Ph.D., Pino Alonso M.D. Ph.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, SpainSearch for more papers by this authorEva Real M.D., Eva Real M.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainSearch for more papers by this authorMarta Subirà M.D., Marta Subirà M.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, SpainSearch for more papers by this authorBlanca Bueno Psych., Blanca Bueno Psych. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainSearch for more papers by this authorSusana Jiménez-Murcia Psych. Ph.D., Susana Jiménez-Murcia Psych. Ph.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain CIBEROBN (Ciber Fisiopatologia Obesidad y Nutrición), Instituto Salud Carlos III, SpainSearch for more papers by this authorJosé M. Menchón M.D. Ph.D., José M. Menchón M.D. Ph.D. OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Institut d' Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, SpainSearch for more papers by this author First published: 26 May 2011 https://doi.org/10.1002/da.20836Citations: 20 † No conflict of interest was declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Background: Neuroimaging and neuropsychological data from patients with an obsessive-compulsive disorder (OCD) indicate the dysfunction of the orbitofrontal cortex (OFC). Olfactory processing has been associated with OFC function, although results from OCD studies regarding this sensory modality have been inconclusive. No previous study has analyzed both odor discrimination and identification capacity in OCD patients using "Sniffin' Sticks" tests. The aim of our study was to assess odor threshold, identification, discrimination, and nonverbal memory in OCD patients, in order to determine whether these functions were affected. Methods: Olfactory function was measured in 29 OCD patients and 29 healthy volunteers (HV) using the "Sniffin' Sticks" test and their nonverbal memory was scored with the Rey–Osterrieth Complex Figure Test. Results: OCD patients showed significant impairment in their odor performance and in their execution of the nonverbal memory task compared to HV. No statistical associations were found between the deficits in the two areas. The severity of depressive and obsessive-compulsive symptoms did correlate with olfactory identification. Conclusion: Our findings support the hypothesis that olfactory and memory dysfunctions in OCD reflect different neurobiological alterations of the disorder, and point to the modulation effect of depressive and obsessive-compulsive symptoms on odor performance. Depression and Anxiety, 2011. © 2011 Wiley-Liss, Inc. Citing Literature Volume28, Issue103 October 2011Pages 932-940 RelatedInformation