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Nanoencapsulation of quercetin and resveratrol into elastic liposomes

2012; Elsevier BV; Volume: 1828; Issue: 2 Linguagem: Inglês

10.1016/j.bbamem.2012.10.022

1879-2642

Pabyton Gonçalves Cadena, Marcela Araújo Pereira, Rafaela B.S. Cordeiro, Isabella Macário Ferro Cavalcanti, Benício B. Neto, Maria do Carmo C.B. Pimentel, José Luiz Lima Filho, Valdinete L. Silva, Nereide Stela Santos-Magalhães,

Advanced Drug Delivery Systems

Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149 nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (− 13.3 mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat.