Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene
1997; Elsevier BV; Volume: 349; Issue: 9059 Linguagem: Inglês
10.1016/s0140-6736(05)63022-x
ISSN1474-547X
AutoresKrishnankutty Sudhir, Tony M. Chou, Louis M. Messina, Stuart J. Hutchison, Kenneth S. Korach, Kanu Chatterjee, Gabor M. Rubanyi,
Tópico(s)Hormonal and reproductive studies
ResumoOestrogens protect against cardiovascular disease in women; 1 Barrett-Connor E Bush TL Estrogen and coronary heart disease in women. JAMA. 1991; 265: 1861-1867 Crossref PubMed Scopus (1207) Google Scholar in men, oestrogens are produced by local tissue aromatisation of androgenic precursors from the testes and adrenal glands. 2 MacDonald PC Madden JD Brenner PF Wilson JD Siiteri PK Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab. 1979; 49: 905-916 Crossref PubMed Scopus (293) Google Scholar Physiological concentrations of oestrogen have been reported to influence plasma high-density lipoprotein cholesterol in men. 3 Bagatell CJ Knopp RH Rivier JE Bremner WJ Physiological levels of estradiol stimulate plasma high density lipoprotein2 cholesterol levels in normal men. J Clin Endocrinol Metab. 1994; 78: 855-861 Crossref PubMed Scopus (84) Google Scholar It is unclear whether oestrogens influence vascular function in men. We studied the peripheral vasculature of a 31-year-old man, with oestrogen resistance caused by a disruptive mutation in the oestrogen-receptor gene, as previously described. 4 Smith EP Boyd J Frank GR et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med. 1994; 331: 1056-1061 Crossref PubMed Scopus (2172) Google Scholar
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