Mechanisms by Which Fibrin and Fibronectin Appear in Healing Wounds: Implications for Peyronie's Disease
1997; Lippincott Williams & Wilkins; Volume: 157; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(01)65366-7
ISSN1527-3792
Autores Tópico(s)Genital Health and Disease
ResumoNo AccessJournal of UrologyInternational Conference on Peyronie's Disease1 Jan 1997Mechanisms by Which Fibrin and Fibronectin Appear in Healing Wounds: Implications for Peyronie's Disease Livingston Van De Water Livingston Van De WaterLivingston Van De Water View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65366-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The extracellular matrix that is present at sites of tissue repair in most instances undergoes an orderly transition from a fibrin containing matrix to collagen-rich scar. However, in some conditions, such as Peyronie's disease, fibrin persists. Evidence from a number of experimental systems indicates that extracellular matrix proteins and their receptors serve an important function in regulating cell behaviors. Thus, the presence of the fibrin matrix is likely to have important implications in the course of either normal or pathogenic wound healing as occurs in Peyronie's disease. Potential mechanisms by which the fibrin rich provisional matrix appears in healing wounds are presented. Materials and Methods: Methodologies, such as in situ hybridization, immunolocalization and labeled tracer techniques, were used in our study. Results: We found by these approaches that the 2 general mechanisms that contribute to the generation of the wound extracellular matrix are leakage of plasma proteins, such as plasma fibronectin and fibrinogen, and the synthesis of variants of fibronectin by wound cells. Conclusions: Developing an understanding of the mechanisms that regulate the appearance of these matrix proteins may provide new avenues for therapy in conditions such as Peyronie's disease in which the temporal pattern of the provisional matrix deposition is abnormal. 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Google Scholar Department of Pathology, Beth Israel Hospital, Center For Engineering in Medicine, Massachusetts General Hospital, Shriners Burns Institute, and Harvard Medical School, Boston, Massachusetts.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 157Issue 1January 1997Page: 306-310 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.Metrics Author Information Livingston Van De Water More articles by this author Expand All Advertisement PDF downloadLoading ...
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