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BIBTEX RIS

Association between uric acid and cardiovascular risk variables in a non-hospitalized population.

2011; Sociedade Brasileira de Cardiologia (SBC); Volume: 96; Issue: 3 Linguagem: Inglês

10.1590/s0066-782x2011005000011

ISSN

1678-4170

Autores

Monica Cristina Campos Barbosa, Andréa Araújo Brandão, Roberto Pozzan, Maria Eliane Campos Magalhães, Érika Maria Gonçalves Campana, Flávia Lopes Fonseca, Oswaldo Luiz Pizzi, Elizabete Viana de Freitas, Ayrton Pires Brandão,

Tópico(s)

Alcohol Consumption and Health Effects

Resumo

The association between uric acid (UA) and cardiovascular risk variables remains a controversial issue in epidemiological studies.To evaluate the association between UA, blood pressure (BP), anthropometric indices and metabolic variables in a non-hospitalized population stratified by UA quintiles.A cross-sectional observational study evaluated 756 individuals (369 males), aged 50.3 ± 16.12 years, divided in UA quintiles. BP, body mass index (BMI), abdominal circumference (AC), UA, glucose, insulin, HOMA-IR, total cholesterol (TC), LDL-c, HDL-c, triglycerides (TG) and creatinine (C) levels were obtained. The estimated glomerular filtration rate (eGFR) was calculated and arterial hypertension (AH) was considered when BP > 140x90 mmHg, overweight/obesity (OW/O) was considered when BMI > 25 kg/m² and metabolic syndrome (MS) was established according to the I Brazilian Guideline of MS.1) There was no difference between the groups regarding the distribution by sex and age range; 2) The highest UA quintiles presented higher mean age (p < 0.01), BMI, AC (p < 0.01), SBP, DBP (p < 0.001), TC, LDL-c, TG (p < 0.01), C and eGFR (p < 0.001) and lower mean HDL-c (p < 0.001); 3) The group with the highest UA quintile showed higher prevalence of AH, OW/O and MS (p < 0.001); 4) Higher percentages of the lowest quintiles of insulin (p < 0.02) and HOMA-IR (p < 0.01) were observed with the lowest quintiles of UA; 5) A logistic regression analysis showed that UA and the variables that compose MS were associated with the occurrence of MS (p < 0.01).Higher quintiles of uric acid were associated with a worse cardiovascular risk profile and a worse kidney function profile in the non-hospitalized population sample studied.

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