Clinicopathological Analysis of Early-Stage Gastric Cancers Detected After Successful Eradication of Helicobacter pylori
2011; Wiley; Volume: 16; Issue: 3 Linguagem: Inglês
10.1111/j.1523-5378.2011.00833.x
ISSN1523-5378
AutoresKeiko Yamamoto, Mototsugu Kato, Masakazu Takahashi, Masahira Haneda, Keisuke Shinada, Urara Nishida, Takeshi Yoshida, Norikazu Sonoda, Shoko Ono, Manabu Nakagawa, Yasuaki Mori, Soichi Nakagawa, Katsuhiro Mabe, Yuichi Shimizu, Jun Moriya, Kanako Kubota, Yoshihiro Matsuno, Tadakazu Shimoda, Hidenobu Watanabe, Masahiro Asaka,
Tópico(s)Genetic factors in colorectal cancer
ResumoHelicobacterVolume 16, Issue 3 p. 210-216 Clinicopathological Analysis of Early-Stage Gastric Cancers Detected After Successful Eradication of Helicobacter pylori Keiko Yamamoto, Keiko Yamamoto Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorMototsugu Kato, Mototsugu Kato Division of Endoscopy, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorMasakazu Takahashi, Masakazu Takahashi Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorMasahira Haneda, Masahira Haneda Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorKeisuke Shinada, Keisuke Shinada Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorUrara Nishida, Urara Nishida Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorTakeshi Yoshida, Takeshi Yoshida Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorNorikazu Sonoda, Norikazu Sonoda Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorShoko Ono, Shoko Ono Division of Endoscopy, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorManabu Nakagawa, Manabu Nakagawa Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorYasuaki Mori, Yasuaki Mori Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorSoichi Nakagawa, Soichi Nakagawa Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorKatsuhiro Mabe, Katsuhiro Mabe Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorYuichi Shimizu, Yuichi Shimizu Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorJun Moriya, Jun Moriya Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorKanako Kubota, Kanako Kubota Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorYoshihiro Matsuno, Yoshihiro Matsuno Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorTadakazu Shimoda, Tadakazu Shimoda Center for Cancer Control and Information Services, National Cancer Center, Tokyo, JapanSearch for more papers by this authorHidenobu Watanabe, Hidenobu Watanabe Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Science, Niigata University, Niigata, JapanSearch for more papers by this authorMasahiro Asaka, Masahiro Asaka Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this author Keiko Yamamoto, Keiko Yamamoto Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorMototsugu Kato, Mototsugu Kato Division of Endoscopy, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorMasakazu Takahashi, Masakazu Takahashi Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorMasahira Haneda, Masahira Haneda Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorKeisuke Shinada, Keisuke Shinada Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorUrara Nishida, Urara Nishida Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorTakeshi Yoshida, Takeshi Yoshida Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorNorikazu Sonoda, Norikazu Sonoda Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorShoko Ono, Shoko Ono Division of Endoscopy, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorManabu Nakagawa, Manabu Nakagawa Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorYasuaki Mori, Yasuaki Mori Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorSoichi Nakagawa, Soichi Nakagawa Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorKatsuhiro Mabe, Katsuhiro Mabe Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorYuichi Shimizu, Yuichi Shimizu Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this authorJun Moriya, Jun Moriya Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorKanako Kubota, Kanako Kubota Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorYoshihiro Matsuno, Yoshihiro Matsuno Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanSearch for more papers by this authorTadakazu Shimoda, Tadakazu Shimoda Center for Cancer Control and Information Services, National Cancer Center, Tokyo, JapanSearch for more papers by this authorHidenobu Watanabe, Hidenobu Watanabe Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Science, Niigata University, Niigata, JapanSearch for more papers by this authorMasahiro Asaka, Masahiro Asaka Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSearch for more papers by this author First published: 18 May 2011 https://doi.org/10.1111/j.1523-5378.2011.00833.xCitations: 52 Reprint requests to: Mototsugu KATO, MD, PhD, Division of Endoscopy, Hokkaido University Hospital, Nishi 5, Kita 14, Kita-ku, Sapporo, Hokkaido 060-8468, Japan. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background and Aims: The results of a randomized controlled study and meta-analysis study have recently proved that Helicobacter pylori eradication has a preventive effect against the development of metachronous and primary gastric cancer. However, gastric cancer is sometimes detected after successful eradication. There is a lack of study about gastric cancers in eradicated patients. To clarify the characteristics of gastric cancers detected after H. pylori eradication, we analyzed the clinicopathological features of these cancers. Methods: The subjects were 18 early-stage gastric cancer specimens resected from 17 patients who had received successful eradication of H. pylori from February 1995 to March 2009. The control group consisted of 36 specimens from noneradicated patients with persistent H. pylori infection who were matched with the subjects in age, sex, and depth of invasion. Clinicopathological features and mucin phenotypes of gastric cancer were clinically and immunohistologically evaluated. Results: The average diameter of gastric cancer was smaller and Ki-67 index was lower in the eradication group. The morphological distribution of depression types was significantly lower in the control group. Immunohistochemical phenotyping revealed that 72.2% of the lesions in the eradicated group were complete gastric type or gastric predominant mixed type, whereas the percentages of gastric type and intestinal type in the control group were similar. Conclusion: Our findings indicate that the clinicopathological characteristics of gastric cancers detected after H. pylori eradication are different from those of gastric cancers in patients with persistent H. pylori infection. H. pylori eradication may suppress intestinalization during the development of gastric cancer. References 1 Fukase K, Kato M, Inoue K, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomized controlled trial. Lancet 2008; 372: 392–7. 2 Lorenzo F, Rocco MZ, Leonardo HE, et al. Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? 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Citing Literature Volume16, Issue3June 2011Pages 210-216 ReferencesRelatedInformation
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