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Contrast-Enhanced Ultrasonography for Assessment of Tumor Vascularity in Hepatocellular Carcinoma

2007; Wiley; Volume: 26; Issue: 6 Linguagem: Inglês

10.7863/jum.2007.26.6.757

1550-9613

Zhili Wang, Jie Tang, Lichun An, Wei Wang, Yukun Luo, Junlai Li, Jianhong Xu,

Ultrasound and Hyperthermia Applications

Journal of Ultrasound in MedicineVolume 26, Issue 6 p. 757-762 Article Contrast-Enhanced Ultrasonography for Assessment of Tumor Vascularity in Hepatocellular Carcinoma Zhili Wang MD, Corresponding Author Zhili Wang MD [email protected] Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Address correspondence to Zhili Wang, MD, Department of Ultrasound, Chinese People's Liberation Army General Hospital, 28 Fuxing Rd, 100853 Beijing, China.Search for more papers by this authorJie Tang MD, Jie Tang MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorLichun An MD, Lichun An MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorWei Wang MD, Wei Wang MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorYukun Luo MD, Yukun Luo MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorJunlai Li MD, Junlai Li MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorJianhong Xu MD, Jianhong Xu MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this author Zhili Wang MD, Corresponding Author Zhili Wang MD [email protected] Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Address correspondence to Zhili Wang, MD, Department of Ultrasound, Chinese People's Liberation Army General Hospital, 28 Fuxing Rd, 100853 Beijing, China.Search for more papers by this authorJie Tang MD, Jie Tang MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorLichun An MD, Lichun An MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorWei Wang MD, Wei Wang MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorYukun Luo MD, Yukun Luo MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorJunlai Li MD, Junlai Li MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this authorJianhong Xu MD, Jianhong Xu MD Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.Search for more papers by this author First published: 01 June 2007 https://doi.org/10.7863/jum.2007.26.6.757Citations: 48Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Objective Studies have shown that angiogenesis is a critical factor for tumor growth and metastasis in a variety of human tumors. Although various methods have been tried to assess vessels in tumors, including microvessel density (MVD), assessment of tumor vessels by radiologic techniques is not well established. The aim of this study was to investigate the efficacy of contrast-enhanced ultrasonography (CEUS) in determining the tumor vascularity of hepatocellular carcinoma (HCC). Methods Contrast-enhanced ultrasonography was done in 50 patients with HCC, which was shown histopathologically through subsequent hepatic resection. A contrast pulse sequencing technique and quantitative auto-tracking contrast quantification software were used to analyze the peak intensity (PI) of HCC. Immunohistochemistry was performed to evaluate the level of MVD in HCC. Then the relationship between PI and the level of MVD was analyzed. Results The mean PIs of HCC and peripheral tissue ± SD were 135. 19 ± 28.16 and 72.91 ± 19.22 dB, respectively. The MVDs of HCC and peripheral tissue were 43.44 ± 12.22 and 17.14 ± 9.18, respectively. The values of PI and MVD of HCC were significantly higher than those of peripheral tissue. A significant correlation was found between PI and MVD in HCC tissues (P < .05). Conclusions The PI in CEUS could reflect the MVD in HCC. Therefore, quantification of CEUS seems to be helpful for assessment of tumor vascularity in HCC. References 1Jaeger TM, Weider N, Chew K, et al. Tumor angiogenesis correlates with lymph node metastasis in invasive bladder cancer. J Urol 1995; 154: 69–71. 2Brown LF, Berse B, Welch WR, et al. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 1995; 26: 86–91. 3Boocock CA, Charnock-Jones DS, Sharkey AM, et al. 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