Tissue distribution of metoprolol‐( 3 H) in the mouse and the rat
1975; Wiley; Volume: 36; Issue: s5 Linguagem: Inglês
10.1111/j.1600-0773.1975.tb03328.x
ISSN0001-6683
AutoresNils‐Olof Bodin, K. O. Borg, Rustan Johansson, Carl‐Henrik Ramsay, Inger Skånberg,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoAbstract: The tissue distribution of specifically tritium‐labelled metoprolol was studied in mice by whole‐body autoradiography and in rats by determination of unchanged drug and the total pool of metabolites in pre‐selceted tissues. The distribution after intravenous administration was characterized by a rapid localization to various tissues e.g. liver, kidney, gall bladder, urinary bladder, salivary glands, Harder's gland, spleen, lungs and adrenals. In the pregnant mouse the drug and/or its metabolites crossed the blood‐placenta barrier and moderate concentrations were found in the foetus. Metoprolol was metabolized to a large extent in the rat and after oral administration the total pool of metabolites exceeded the concentration of unchanged drug in the tissues studied.
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