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Antimicrobial susceptibility of Streptococcus pyogenes in Central, Eastern, and Baltic European Countries, 2005 to 2006: the cefditoren surveillance program

2009; Elsevier BV; Volume: 64; Issue: 1 Linguagem: Inglês

10.1016/j.diagmicrobio.2008.12.018

1879-0070

Matilde Gracia, C. Caramelo Díaz, Pilar Coronel, Mercedes Gimeno, Rocío García‐Rodas, Violeta Rodríguez-Cerrato, Gema del Prado, Lorena Huelves, Vicente Ausina Ruiz, Plínio F.L. Naves, M.C. Ponte, Juan José Granizo, Francisco García Soriano,

Pneumonia and Respiratory Infections

The in vitro activity of penicillin, ampicillin, cefditoren, cefotaxime, erythromycin, clarithromycin, and levofloxacin against 763 clinical isolates of Streptococcus pyogenes was determined. Clinically significant isolates collected from November 2005 to December 2006 in the Czech Republic, Slovakia, Hungary, Poland, Romania, Estonia, Latvia, and Lithuania (the latter 3 analyzed as Baltic countries) were studied. No resistance to β-lactams and levofloxacin was found. The rate of erythromycin resistance in S. pyogenes varied among countries, being low ( 25%) in Hungary and Slovakia. The predominant (75.0%) erythromycin-resistant phenotype among S. pyogenes isolates was MLSB. The identification of the prevalence of erythromycin resistance mechanism could have impact on the choice of empiric antibiotic therapy for the clinicians in such countries.