Characterization of Mutations in DNA Gyrase and Topoisomerase IV Involved in Quinolone Resistance of Mycoplasma gallisepticum Mutants Obtained In Vitro
2002; American Society for Microbiology; Volume: 46; Issue: 2 Linguagem: Inglês
10.1128/aac.46.2.590-593.2002
ISSN1098-6596
AutoresAnita Reinhardt, Cécile Bébéar, M. Kobisch, Isabelle Kempf, Anne V. Gautier‐Bouchardon,
Tópico(s)Plant Virus Research Studies
ResumoABSTRACT Mycoplasma gallisepticum enrofloxacin-resistant mutants were generated by stepwise selection in increasing concentrations of enrofloxacin. Alterations were found in the quinolone resistance-determining regions of the four target genes encoding DNA gyrase and topoisomerase IV from these mutants. This is the first description of such mutations in an animal mycoplasma species.
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