A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier
2011; Wiley; Volume: 6; Issue: 12 Linguagem: Inglês
10.1002/cmdc.201100355
ISSN1860-7187
AutoresMarion Grinda, Jonathan Clarhaut, Isabelle Tranoy‐Opalinski, Brigitte Renoux, Arnaud Monvoisin, Laurent Cronier, Sébastien Papot,
Tópico(s)Signaling Pathways in Disease
ResumoAmplified action! We developed the therapeutic first targeting system that includes a chemical amplifier programmed both to release two potent anticancer drugs after a single enzymatic activation step and become cytotoxic itself once the amplification process is completed. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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