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13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis

2011; Wiley; Volume: 16; Issue: 4 Linguagem: Inglês

10.1111/j.1523-5378.2011.00863.x

1523-5378

Yelda A. Leal, Laura Flores, Ezequiel M. Fuentes‐Pananá, Roberto Cedillo‐Rivera, Javier Torres,

Microbial Metabolites in Food Biotechnology

HelicobacterVolume 16, Issue 4 p. 327-337 13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis Yelda A. Leal, Yelda A. Leal Unidad de Investigación Médica Yucatán (UIMY), Unidad Médica de Alta Especialidad de Mérida, Instituto Mexicano del Seguro Social, Mérida, Yuc, MéxicoSearch for more papers by this authorLaura L. Flores, Laura L. Flores Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and the University of California, San Francisco, CA, USASearch for more papers by this authorEzequiel M. Fuentes-Pananá, Ezequiel M. Fuentes-Pananá Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, DF, MexicoSearch for more papers by this authorRoberto Cedillo-Rivera, Roberto Cedillo-Rivera Unidad de Investigación Médica Yucatán (UIMY), Unidad Médica de Alta Especialidad de Mérida, Instituto Mexicano del Seguro Social, Mérida, Yuc, MéxicoSearch for more papers by this authorJavier Torres, Javier Torres Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, DF, MexicoSearch for more papers by this author Yelda A. Leal, Yelda A. Leal Unidad de Investigación Médica Yucatán (UIMY), Unidad Médica de Alta Especialidad de Mérida, Instituto Mexicano del Seguro Social, Mérida, Yuc, MéxicoSearch for more papers by this authorLaura L. Flores, Laura L. Flores Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and the University of California, San Francisco, CA, USASearch for more papers by this authorEzequiel M. Fuentes-Pananá, Ezequiel M. Fuentes-Pananá Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, DF, MexicoSearch for more papers by this authorRoberto Cedillo-Rivera, Roberto Cedillo-Rivera Unidad de Investigación Médica Yucatán (UIMY), Unidad Médica de Alta Especialidad de Mérida, Instituto Mexicano del Seguro Social, Mérida, Yuc, MéxicoSearch for more papers by this authorJavier Torres, Javier Torres Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, DF, MexicoSearch for more papers by this author First published: 18 July 2011 https://doi.org/10.1111/j.1523-5378.2011.00863.xCitations: 70 Reprint requests to: Yelda A. Leal, Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad del Centro Médico Nacional “Ignacio García Téllez” Mérida Yucatán, Instituto Mexicano del Seguro Social, Calle 34 #439 x 41 Colonia Industrial (Ex-terrenos del Fénix, Hospital T1), Mérida, Yucatán 97150, México. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background: The 13C-urea breath test (13C-UBT) is a safe, noninvasive and reliable method for diagnosing H. pylori infection in adults. However, the test has shown variable accuracy in the pediatric population, especially in young children. We aimed to carry out a systematic review and meta-analysis to evaluate the performance of the 13C-UBT diagnostic test for H. pylori infection in children. Methods: We conducted a systematic review of the PubMed, Embase and Liliacs databases including studies from January 1998 to May 2009. Selection criteria included studies with at least 30 children and reporting the comparison of 13C-UBT against a gold standard for H. pylori diagnosis. Thirty-one articles and 135 studies were included for analysis. Children were stratified in subgroups of 6 years (sensitivity 96.6%, specificity 97.7%, LR+ 42.6, LR− 0.04, DOR 1042.7), 3, greater variability in accuracy estimates and on average a few percentage points lower, particularly specificity, in children ≤6 years (sensitivity 95%, specificity 93.5%, LR+ 11.7, LR− 0.12, DOR 224.8). 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