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A systems view of mRNP biology

2004; Cold Spring Harbor Laboratory Press; Volume: 18; Issue: 23 Linguagem: Inglês

10.1101/gad.1256904

1549-5477

Haley Hieronymus, Pamela A. Silver,

RNA modifications and cancer

Gene expression occurs through a complex mRNA-protein (mRNP) system that stretches from transcription to translation. Gene expression processes are increasingly studied from global perspectives in order to understand their pathways, properties, and behaviors as a system. Here we review these beginnings of mRNP systems biology, as they have emerged from recent large-scale investigation of mRNP components, interactions, and dynamics. Such work has begun to lay the foundation for a broader, integrated view of mRNP organization in gene expression.