Artigo Revisado por pares

Postprocedure creatine kinase-MB elevation and baseline left ventricular dysfunction predict one-year mortality after percutaneous coronary intervention

2002; Elsevier BV; Volume: 89; Issue: 5 Linguagem: Inglês

10.1016/s0002-9149(01)02299-8

ISSN

1879-1913

Autores

George Dangas, Roxana Mehran, Dmitriy N. Feldman, Athanasios Stoyioglou, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Martin Fahy, Alexandra J. Lansky, Gregg W. Stone, Martin B. Leon,

Tópico(s)

Acute Myocardial Infarction Research

Resumo

Cardiac enzyme elevation after percutaneous coronary intervention (PCI) has been associated with diffuse atherosclerosis and increased late mortality even after successful revascularization. 1 Mehran R Dangas G Mintz G.S Lansky A.J Pichard A.D Satler L.F Kent K.M Stone G.W Leon M.B Atherosclerotic plaque burden and CK-MB enzyme elevation after coronary interventions. Intravascular ultrasound study of 2,256 patients. Circulation. 2000; 101: 604-610 Crossref PubMed Scopus (252) Google Scholar , 2 Abdelmeguid A.E Topol E.J Whitlow P.L Sapp S.K Ellis S.G Significance of mild transient release of creatine kinase-MB fraction after percutaneous coronary interventions. Circulation. 1996; 94: 1528-1536 Crossref PubMed Scopus (376) Google Scholar , 3 Kugelmass A.D Cohen D.J Moscucci M Piana R.N Senerchia C Kuntz R.E Baim D.S Elevation of the creatine kinase myocardial isoform following otherwise successful directional coronary atherectomy and stenting. 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JAMA. 1997; 277: 461-466 Crossref PubMed Google Scholar Many studies have also emphasized the dominant prognostic significance of left ventricular (LV) systolic function in patients with coronary artery disease. 9 Vlietstra R.E Assad-Morell J.L Frye R.L Elveback L.R Connolly D.C Ritman E.L Pluth J.R Barnhorst D.A Danielson G.K Wallace R.B Survival predictors in coronary artery disease. Medical and surgical comparisons. Mayo Clin Proc. 1977; 52: 85-90 PubMed Google Scholar , 10 Hammermeister K.E DeRouen T.A Dodge H.T Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations. Circulation. 1979; 59: 421-430 Crossref PubMed Scopus (580) Google Scholar , 11 Nelson G.R Cohn P.F Gorlin R Prognosis in medically-treated coronary artery disease influence of ejection fraction compared to other parameters. 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Circulation. 1994; 90: 2645-2657 Crossref PubMed Google Scholar After coronary artery bypass surgery, increases in late mortality correlated closely with falling values of LV ejection fraction (EF). 14 Risum O Nitter-Hauge S Abdelnoor M Levorstad K Arafa O Svennevig J.L Mortality and morbidity after coronary artery bypass surgery related to preoperative left ventricular ejection fraction a follow up study. Eur Heart J. 1996; 17: 874-879 Crossref PubMed Scopus (26) Google Scholar Furthermore, decreased LVEF and congestive heart failure have been found to predict in-hospital mortality after PCI. 15 Anderson R.D Ohman E.M Holmes Jr, D.R Harrinton R.A Barsness G.W Wildermann N.M Phillips H.R Toppol E.J Califf R.M Prognostic value of CHFhistory in patients undergoing percutaneous coronary interventions. J Am Coll Cardiol. 1998; 32: 936-941 Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar , 16 Harrell L Schunkert H Palacios I.F Risk predictors in patients scheduled for percutaneous coronary revascularization. Cathet Cardiovasc Intervent. 1999; 48: 253-260 Crossref PubMed Scopus (25) Google Scholar , 17 O'Connor G.T Malenka D.J Quinton H Robb J.F Kellet Jr, M.A Shubrooks S Bradley W.A Hearne M.J Watkins M.W Wennberg D.E et al. Multivariate prediction of in-hospital mortality after percutaneous coronary interventions in1994–1996: Northern New England Cardiovascular Disease Study Group. J Am Coll Cardiol. 1999; 34: 681-691 Abstract Full Text Full Text PDF PubMed Scopus (140) Google Scholar This study examined the interaction between decreased LVEF and creatine kinase (CK)-MB elevation after PCI.

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