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PGC-1 Proteins and Heart Failure

2012; Elsevier BV; Volume: 22; Issue: 4 Linguagem: Inglês

10.1016/j.tcm.2012.07.003

1873-2615

Christian Riehle, E. Dale Abel,

Adipokines, Inflammation, and Metabolic Diseases

The transcriptional coactivators PGC-1α and PGC-1β are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1α and PGC-1β gene expression. Maintaining expression of PGC-1α and -β preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.