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Two Salmonella OmpC K b -Restricted Epitopes for CD8 + -T-Cell Recognition

2004; American Society for Microbiology; Volume: 72; Issue: 5 Linguagem: Inglês

10.1128/iai.72.5.3059-3062.2004

1098-5522

José Alberto Dí­az-Quiñónez, Natalia Martín‐Orozco, Armando Isibasi, Vianney Ortiz‐Navarrete,

RNA Interference and Gene Delivery

ABSTRACT We report the identification of two peptides from Salmonella OmpC porin that can bind to major histocompatibility complex class I K b molecules and are targets of cytotoxic T lymphocytes from Salmonella -infected mice. These peptides are conserved in gram-negative bacterial porins and are the first Salmonella porin-specific epitopes described for possible CD8 + -T-cell elimination of infected cells.