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Inhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calcium

1991; Royal Society; Volume: 246; Issue: 1317 Linguagem: Inglês

10.1098/rspb.1991.0148

1471-2954

Frank Zufall, Gordon M. Shepherd, Stuart Firestein,

Insect Pheromone Research and Control

Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Zufall Frank , Shepherd Gordon M. and Firestein Stuart 1991Inhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calciumProc. R. Soc. Lond. B.246225–230http://doi.org/10.1098/rspb.1991.0148SectionRestricted accessArticleInhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calcium Frank Zufall Google Scholar Find this author on PubMed Search for more papers by this author , Gordon M. Shepherd Google Scholar Find this author on PubMed Search for more papers by this author and Stuart Firestein Google Scholar Find this author on PubMed Search for more papers by this author Frank Zufall Google Scholar Find this author on PubMed , Gordon M. Shepherd Google Scholar Find this author on PubMed and Stuart Firestein Google Scholar Find this author on PubMed Published:23 December 1991https://doi.org/10.1098/rspb.1991.0148AbstractWhen olfactory receptor neurons are exposed to sustained application of odours, the elicited ionic current is transient. This adaptation-like effect appears to require the influx of Ca2+ through the odour-sensitive conductance; in the absence of extracellular Ca2+ the current remains sustained. Odour transduction proceeds through a G-protein-based second messenger system, resulting finally in the direct activation of an ion channel by cyclic AMP. This channel is one possible site for a negative feedback loop using Ca2+ as a messenger. In recordings of single cyclic AMP gated channels from olfactory receptor neurons, the open probability of the channel in saturating cAMP concentrations was dependent on the concentration of intracellular Ca2+. It could be reduced from 0.6 in 100 nM C a2+ to 0.09 in 3 |4.m Ca2+. However, as neither the single channel conductance nor the mean open time were affected by Ca2+ concentration, this does not appear to be a mechanism of simple channel block. Rather, these results suggest that intracellular Ca2+ acts allosterically to stabilize a closed state of the channel.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. Previous ArticleNext Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Boccaccio A, Menini A and Pifferi S (2021) The cyclic AMP signaling pathway in the rodent main olfactory system, Cell and Tissue Research, 10.1007/s00441-020-03391-7, 383:1, (429-443), Online publication date: 1-Jan-2021. 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