GERI-BP001 Compounds, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase from Aspergillus fumigatus F37. I. Production, Isolation, and Physico-chemical and Biological Properties.
1995; Springer Nature; Volume: 48; Issue: 8 Linguagem: Inglês
10.7164/antibiotics.48.751
ISSN1881-1469
AutoresTae‐Sook Jeong, Sung-Uk Kim, Kwang-Hee Son, Byoung‐Mog Kwon, Young‐Kook Kim, Myung‐Un Choi, Song‐Hae Bok,
Tópico(s)Plant biochemistry and biosynthesis
ResumoGERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 μM, respectively.
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