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Endoneurial injection of antisera to myelin antigens

1985; Wiley; Volume: 8; Issue: 6 Linguagem: Inglês

10.1002/mus.880080607

1097-4598

Richard AC Hughes, Henry C. Powell, S. L. Braheny, Steven W. Brostoff,

Botulinum Toxin and Related Neurological Disorders

Abstract When antisera to purified myelin antigens were injected into rat sciatic nerves, some produced significant demyelination, whereas others merely induced an inflammatory infiltrate. Extensive demyelination was produced by antisera to galactocerebroside and the peripheral nerve glycoprotein P 0 . Demyelination resulting from injections of antisera to ganglioside GM 1 , P 2 , myelin basic protein, sulfatide, and glucocerebroside did not exceed that produced by normal rabbit serum. Addition of guinea pig complement had no effect. It is of interest that the greatest demyelination followed injection of antisera to two molecules, galactocerebroside and P 0 , the main antigenic determinants of which present at the Schwann cell surface.