CFTR and Bicarbonate Secretion to Epithelial Cells
2003; American Physiological Society; Volume: 18; Issue: 1 Linguagem: Inglês
10.1152/nips.01412.2002
ISSN1548-9213
AutoresMartin J. Hug, Tsutomu Tamada, Robert J. Bridges,
Tópico(s)Infant Development and Preterm Care
ResumoDefective HCO 3 – and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO 3 – secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO 3 – .
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