Ethyl alkynyl ethers: A convenient ketene source for lactone formation
1993; Elsevier BV; Volume: 49; Issue: 11 Linguagem: Inglês
10.1016/s0040-4020(01)80360-4
ISSN1464-5416
AutoresLi Liang, Mahesh Ramaseshan, David I. MaGee,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoA convenient and general method for the preparation of lactones of varying size via the intramolecular trapping of a ketene has been developed. Simple thermolysis of various ethoxy acetylene derivatives at 150°C for 2 hours produced the desired compounds in yields ranging from 30%–75%. The addition of tri-n-butylamine was required to achieve reasonable yields for medium and large rings.
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