Portal de Periódicos da CAPES

Increased melanoma formation and dissemination in T yr NR as mice deficient in the tumor suppressor I ng1

2014; Wiley; Volume: 27; Issue: 4 Linguagem: Inglês

10.1111/pcmr.12241

1755-148X

Camino Menéndez, Isabel Adrados, Asunción Fernández‐Barral, Benilde Jiménez, Juana M Flores, Marta Cañamero, Ernst‐Martin Füchtbauer, Friedrich Beermann, Ignacio Palmero,

Cell Adhesion Molecules Research

Figure S1. Normal skin of TyrNRas/Ing1−/− mice, and melanoma incidence and percentage of lung or lymph node metastasis in TyrNRas/Ink4a/Arf−/− mice. Figure S2. Macroscopic appearance of melanocytic lesions in Ing1−/− mice and TRP2 immunohistochemistry of locally invasive TyrNRas/Ing1−/− lesions. TRP2 and Ki-67 staining of representative TyrNRas/wt and TyrNRas/Ing1+/− melanomas. Figure S3. Specificity of p19Arf IHC in melanin-rich melanomas. Figure S4. Western blot of p19Arf and p53 in melanomas of different Ing1 genotypes. Figure S5. Representative Western blot and quantification of p33ING1 protein in human melanoma cell lines. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.