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Identification of a potential RNA intermediate for transposition of the LINE-like element I factor in Drosophila melanogaster.

1990; Springer Nature; Volume: 9; Issue: 11 Linguagem: Inglês

10.1002/j.1460-2075.1990.tb07566.x

1460-2075

Marie‐Christine Chaboissier, Isabelle Busseau, J. Prosser, David Finnegan, Alain Bucheton,

RNA Research and Splicing

Research Article1 November 1990free access Identification of a potential RNA intermediate for transposition of the LINE-like element I factor in Drosophila melanogaster. M. C. Chaboissier M. C. Chaboissier Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author I. Busseau I. Busseau Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author J. Prosser J. Prosser Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author D. J. Finnegan D. J. Finnegan Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author A. Bucheton A. Bucheton Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author M. C. Chaboissier M. C. Chaboissier Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author I. Busseau I. Busseau Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author J. Prosser J. Prosser Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author D. J. Finnegan D. J. Finnegan Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author A. Bucheton A. Bucheton Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. Search for more papers by this author Author Information M. C. Chaboissier1, I. Busseau1, J. Prosser1, D. J. Finnegan1 and A. Bucheton1 1Laboratoire de Génétique, Université Blaise Pascal, Aubière, France. The EMBO Journal (1990)9:3557-3563https://doi.org/10.1002/j.1460-2075.1990.tb07566.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The I factor, a transposable element related to mammalian LINEs, controls the I-R system of hybrid dysgenesis in Drosophila melanogaster. It transposes at high frequency in the germ-line of the female progeny of crosses between females of the reactive class of strains and males of the inducer class. The structure and DNA sequence of the I factor suggest that it transposes by reverse transcription of an RNA intermediate. Northern blot and S1 mapping experiments show that a full-length RNA of the I factor is synthesized specifically in the conditions of which I factors transpose. This RNA has all characteristics of a transposition intermediate. It is only found in the ovaries of dysgenic females suggesting that I factor activity is restricted to this tissue because of regulation at the level of the initiation of transcription or RNA stability. Previous ArticleNext Article Volume 9Issue 111 November 1990In this issue RelatedDetailsLoading ...