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Torcetrapib impairs endothelial function in hypertension

2011; Oxford University Press; Volume: 33; Issue: 13 Linguagem: Inglês

10.1093/eurheartj/ehr348

1522-9645

Branko Simic, Matthias Hermann, Sidney Shaw, Laurent Bigler, Urs Stalder, Carola Dörries, Christian Besler, Thomas F. Lüscher, Frank Ruschitzka,

Eicosanoids and Hypertension Pharmacology

AimsA marked increase in HDL notwithstanding, the cholesterol ester transfer protein (CETP) inhibitor torcetrapib was associated with an increase in all-cause mortality in the ILLUMINATE trial. As underlying mechanisms remain elusive, the present study was designed to delineate potential off-target effects of torcetrapib.