Localization of androgen receptor expression in human bone marrow
2001; Volume: 193; Issue: 3 Linguagem: Inglês
10.1002/1096-9896(0000)9999
ISSN1096-9896
AutoresAthanasios Mantalaris, Nicki Panoskaltsis, Yasuyuki Sakai, Patricia A. Bourne, Chawnshang Chang, Edward M. Messing, Jiangbin Wu,
Tópico(s)Acute Myeloid Leukemia Research
ResumoAndrogens have been shown to modulate the haematopoietic and immune systems and have been used clinically for stimulating haematopoiesis in bone marrow failure conditions. To identify the bone marrow cell types as potential targets of androgens, an androgen receptor (AR)-specific antibody was used to localize the AR in normal human bone marrow biopsies. The results show that AR was ubiquitously expressed in the bone marrow of both males and females. Furthermore, the AR expression pattern did not change with age. Stromal cells, macrophages, endothelial cells, myeloblasts, myelocytes, neutrophils, and megakaryocytes expressed AR. In contrast, AR was not detected in the lymphoid and erythroid cells, or in eosinophils. These results indicate that androgens may exert direct modulating effects on a wide spectrum of bone marrow cell types via AR-mediated responses.
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