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Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway

2005; Oxford University Press; Volume: 20; Issue: 12 Linguagem: Inglês

10.1093/ndt/gfi133

1460-2385

Leda Márcia Araújo Bento, José Barreto Campello Carvalheira, Leonardo Fantinato Menegon, Mário J. A. Saad, José Antônio Rocha Gontijo,

Nitric Oxide and Endothelin Effects

Background. There is a surprising lack of experimental data on the mechanisms of NH4Cl-induced chronic metabolic acidosis which causes kidney hypertrophy. The NH4Cl treatment results in an absolute increase in kidney mass. Despite findings to indicate a close interaction between NH4Cl-induced chronic metabolic acidosis and renal enlargement, the role of the stimulated serine kinase cascade, mediated by the stepwise activation of extracellular signal-regulated kinase (ERK) signalling, on kidney hypertrophy has not yet been investigated.