Total synthesis of indole and dihydroindole alkaloids. XVI. Derivatives of vinblastine and vincristine: change of functionality in the vindoline unit
1978; NRC Research Press; Volume: 56; Issue: 19 Linguagem: Inglês
10.1139/v78-420
ISSN1480-3291
AutoresJames P. Kutney, John Balsevich, Toshio Honda, Ping-Huang Liao, Herman P. M. Thieelier, Brian R. Worth,
Tópico(s)Chromatography in Natural Products
ResumoStudies describing the preparation of various derivatives of vinblastine and vincristine are presented. Vindoline (3) is transformed into a series of derivatives and the latter via Polonovski-type coupling with catharanthine (2) provide the bisindole alkaloid derivatives of the vinblastine series. Selective Jones' oxidation transforms the vinblastine family into the corresponding vincristine derivatives.
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