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BIBTEX RIS

Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates

2009; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 104; Issue: 7 Linguagem: Inglês

10.1590/s0074-02762009000700012

ISSN

1678-8060

Autores

Bianca Ervatti Gama, Natália K Almeida de Oliveira, José Maria de Souza, Cláudio Tadeu Daniel‐Ribeiro, Maria de Fátima Ferreira‐da‐Cruz,

Tópico(s)

Hepatitis B Virus Studies

Resumo

Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed.

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