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Coenzyme Q10 Supplementation and Heart Failure

2008; Oxford University Press; Volume: 65; Issue: 6 Linguagem: Inglês

10.1111/j.1753-4887.2007.tb00306.x

1753-4887

Uma Shankar Singh, Sridevi Devaraj, Ishwarlal Jialal,

Biochemical Acid Research Studies

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western world. Oxida-tive stress appears to play a pivotal role in atherosclerosis. Coenzyme Q10 (CoQ10), one of the most important antioxidants, is synthesized de novo by every cell in the body. Its biosynthesis decreases with age and its deficit in tissues is associated with degenerative changes of aging, thus implicating a possible therapeutic role of CoQ10 in human diseases. There is evidence to support the therapeutic value of CoQ10 as an adjunct to standard medical therapy in congestive heart failure. However, much further research is required, especially in the use of state-of-the-art techniques to assess functional outcomes in patients with congestive heart failure.