Vancomycin resistance in enterococci: reprogramming of the d-Ala–d-Ala ligases in bacterial peptidoglycan biosynthesis
2000; Elsevier BV; Volume: 7; Issue: 5 Linguagem: Inglês
10.1016/s1074-5521(00)00116-2
ISSN1879-1301
AutoresVicki L Healy, Ivan A. D. Lessard, David I. Roper, James R. Knox, Christopher T. Walsh,
Tópico(s)Bacterial Genetics and Biotechnology
ResumoAbstract Vancomycin binds to bacterial cell-wall intermediates to achieve its antibiotic effect. Infections of vancomycin-resistant enterococci are, however, becoming an increasing problem; the bacteria are resistant because they synthesize different cell-wall intermediates. The enzymes involved in cell-wall biosynthesis, therefore, are potential targets for combating this resistance. Recent biochemical and crystallographic results are providing mechanistic and structural details about some of these targets.
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