Catalytic Asymmetric exo′ ‐Selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin‐3,3′‐oxindole]s
2012; Wiley; Volume: 18; Issue: 27 Linguagem: Inglês
10.1002/chem.201201249
ISSN1521-3765
Autores Tópico(s)Synthesis and Catalytic Reactions
ResumoThe first catalytic asymmetric exo′-selective [3+2] cycloaddition of methyleneindolinones with iminoesters was achieved for construction of novel diastereomers of spiro[pyrrolidin-3,3′-oxindole]. By using the imidazoline–aminophenol-ligand complex [Ni(OAc)2–(L1)], the reaction proceeds in the stepwise Michael–Mannich reaction to give the exo′ adducts as stable isomers (see scheme). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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