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The effect of an intermediate dose of labetalol on heart rate and blood pressure responses to laryngoscopy and intubation

1992; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês

10.1016/0952-8180(92)90112-e

1873-4529

Keun Sam Chung, Raymond S. Sinatra, J. H. Chung,

Hemodynamic Monitoring and Therapy

To evaluate the efficacy of an intermediate dose of labetalol (0.4 mg/kg) for attenuation of heart rate (HR) and blood pressure (BP) responses to laryngoscopy and intubation.Randomized, double-blind, placebo-controlled study.Inpatient gynecology service at a university medical center.Two groups of 18 patients each undergoing elective surgery under general anesthesia.Patients received either 0.4 mg/kg of labetalol or an equal volume of normal saline 5 minutes prior to laryngoscopy and intubation.HR and BP were measured upon arrival in the operating room (OR) (baseline) and at 1 minute intervals thereafter for 4 minutes prior to intubation and through 10 minutes following intubation. The labetalol group had a significantly lower HR from induction through 1 minute following intubation. Intragroup differences in HR were greatest immediately following laryngoscopy and intubation (33% increase above baseline for the placebo group vs 1% for the labetalol group, p less than 0.05). At the same time, a significant increase in mean arterial pressure (MAP) from baseline was noted in both groups (29% for the placebo group vs 23% for the labetalol group), but the difference between the groups was not significant.An intermediate dose of labetalol blunted the HR response to laryngoscopy and intubation during rapid-sequence induction in healthy patients but had a minimal effect on BP.