Portal de Periódicos da CAPES

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994; American Association for the Advancement of Science; Volume: 264; Issue: 5161 Linguagem: Inglês

10.1126/science.8178155

1095-9203

Kenneth H. Grabstein, June Eisenman, Kurt Shanebeck, Charles T. Rauch, Subhashini Srinivasan, Victor Fung, Courtney Beers, Jane S. Richardson, M A Schoenborn, Minoo Ahdieh, Lisabeth Johnson, Mark R. Alderson, James D. Watson, Dirk M. Anderson, Judith G. Giri,

T-cell and Retrovirus Studies

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.