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Identification of Tetrahydronorharmane (Tetrahydro-β-carboline) in Human Blood Platelets

1980; De Gruyter; Volume: 18; Issue: 2 Linguagem: Inglês

10.1515/cclm.1980.18.2.133

1437-4331

H. Honecker, H. Coper, Christa Fähndrich, Hans Rommelspacher,

Drug Transport and Resistance Mechanisms

The present paper shows that tetrahydronorharmane (tetrahydro-0-carboline) exists in human platelets.The concentration of tetrahydronorharmane in platelets from 10 ml platelet rich plasma was in the range of 9.3 to 25.6 pmol (n=8).Ingestion of tryptamine hydrochloride (n=4) three times daily for three consecutive days and of 19.6 mmol Z)^-tryptophan (n=7) the evening (10 p. m.) before the blood collection did not lead to an increase of tetrahydronorharmane in platelets. Nachweis von Tetrahydronorharman (Tetrahydro-ß-carbolin) in menschlichen ThrombocytenZusammenfassung: In der vorliegenden Arbeit wird das Vorkommen von Tetrahydronorharman (Tetrahydro-j3carbolin) in menschlichen Thrombocyten nachgewiesen.Der Gehalt der Thrombocyten aus 10 ml plättchenreichem Plasma an Tetrahydronorharman lag in dem Bereich von 9,3 bis 25,6 pmol (n=8).Einnahme von Tryptaminhydrochlorid (n=4) dreimal