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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Investigation of liver tissue and biochemical parameters of adult wistar rats treated with Arctium lappa L.

2009; Instituto de Tecnologia do Paraná (Tecpar); Volume: 52; Issue: 2 Linguagem: Inglês

10.1590/s1516-89132009000200010

ISSN

1678-4324

Autores

Fabrícia de Souza Predes, Sérgio Luís Pinto da Matta, Juliana Castro Monteiro, Tânia Toledo de Oliveira,

Tópico(s)

Liver Disease Diagnosis and Treatment

Resumo

This study was carried out to evaluate the effects of Arctium lappa L. (burdock) on the liver of adult male Wistar rats as measured by light microscopy and biochemical parameters. The rats received the extract in water bottles at doses of 10 or 20 g/L daily for 40 days. There were no significant changes in the plasma levels of albumin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT), total protein, total cholesterol, urea, uric acid, triacylglycerol, calcium, phosphorus, chlorine and direct bilirubin. The morphological analysis did not reveal histopathological alterations in liver tissue. Both biochemical and morphological data did not indicate A. lappa toxicity.

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