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Detection of Norwalk Virus or Norwalk-like Virus Infections in Finnish Infants and Young Children

1994; Oxford University Press; Volume: 169; Issue: 6 Linguagem: Inglês

10.1093/infdis/169.6.1364

1537-6613

Judy Lew, J Valdesuso, Timo Vesikari, A Z Kapikian, Xiaofang Jiang, Mary K. Estes, K Y Green,

Viral Infections and Outbreaks Research

Norwalk virus (NV) and Norwalk-like viruses are important causes of epidemic nonbacterial gastroenteritis in older children and adults. Serologic responses to NV of 154 Finnish infants and young children participating in a rotavirus vaccine study were examined by ELISA with a recently available baculovirus-expressed recombinant NV capsid protein. In 4 serially collected sera (at the median ages of 3, 4, 14, and 23 months), 49% of children had at least one NV infection over the ∼2-year study period. Children with low NV-specificIgG titers ( 1:50) (P < .05). Thus, NV or Norwalk-like virus infections are more common in infants and young children than previously believed, and antibody to NV may be protective against such infections.