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Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme

2005; Elsevier BV; Volume: 13; Issue: 12 Linguagem: Inglês

10.1016/j.bmc.2005.03.045

1464-3391

Marcelo T. Andrade, Josélia Alencar Lima, Ângelo C. Pinto, Cláudia M. Rezende, Meriane P. Carvalho, Rosângela A. Epifanio,

Cholinesterase and Neurodegenerative Diseases

Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis (Müell. Arg) Miers were tentatively identified by GC–MS, viz., coronaridine (1), voacangine (2), voacangine hydroxyindolenine (3), rupicoline (4), ibogamine (5), ibogaine (6), ibogaline (7), desethyl-voacangine (8), voachalotine (9), and affinisine (10). Of these, the first four were isolated by silica gel open column chromatography, identified by uni- and bidimensional NMR, IR, MS and showed anti-cholinesterasic activity at the same concentration as the reference compounds physostigmine and galanthamine (detection limit of 0.01 mM) by TLC assay using the modified Ellman's method.